Fractionation Mapping by Using a High-density Catheter to Map Ganglionated Plexus Sites During Sinus Rhythm

DOI: 10.19102/icrm.2021.120110S

JOSE OSORIO, MD,¹ DOUGLAS MACKENZIE DOUD, MSBME, CEPS,² and TOLGA AKSU, MD³

¹Grandview Medical Center, Birmingham, AL, USA

²Abbott, Chicago, IL, USA

³University of Health Sciences, Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey

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KEYWORDS. Cardiomyopathy, epicardial, high-density mapping, ventricular tachycardia.

The authors report no conflicts of interest for the published content.
Address correspondence to: Tolga Aksu, MD. Email: aksutolga@gmail.com.

Ablation of the ganglionated plexi (GPs) is a relatively new technique aiming to prevent the autonomic imbalance in vasovagal syncope (VVS) from occurring. To confirm localization of the GPs, the potential usage of fragmented electrograms with visual analysis was firstly defined by our group.¹ However, decisions made by humans based on the visual review of data may demonstrate low reproducibility.

As a new software, the fractionation mapping tool of the EnSite Precision™ cardiac mapping system was successfully used to detect GP sites during atrial fibrillation.² A 18-year-old male with cardioinhibitory-type VVS was admitted with recurrent syncopal episodes despite physical counterpressure maneuvers and medications. The right and left atria were mapped with the Advisor™ HD Grid Mapping Catheter, Sensor Enabled™. Bipolar recordings were filtered at 200 to 500 Hz. A fractionation map was created using combinations of width (5 ms), refractory time (30 ms), roving sensitivity (0.1 mV), and fractionation threshold.² Technical details were discussed in our previous work.³ White areas on the map were accepted as potential GP sites and defined as targets of ablation (Figure 1). After all GP targets were identified, radiofrequency ablation of the targeted areas was initiated according to our ablation order of GPs (ie, the left superior GP, the Marshall tract GP, the left inferior GP, the right superior GP via the left atrium, and the right inferior GP via the left atrium, respectively.⁴ Radiofrequency energy application at left-sided GPs triggered a vagal response with sinus bradycardia. Meanwhile, during radiofrequency ablation at the right superior GP, the patient’s heart rate increased from 976 to 620 ms (Video 1). The procedure was ended with ablation of the right superior GP via the right atrium. The final P–R interval was detected as 110 ms, which was comparable with preoperative atropine challenge results. The use of fractionation mapping software with application of the Advisor™ HD Grid mapping catheter may be used to localize GPs.

References

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